4-Iodophenylboronic Acid (contains varying amounts of Anhydride)
Catalog Number
ACM5122996-1
CAS
5122-99-6
IUPAC Name
(4-iodophenyl)boronic acid
Synonyms
4-Iodobenzeneboronic Acid (contains varying amounts of Anhydride)
Application
4-Iodophenylboronic Acid, a white crystalline powder containing varying amounts of anhydride, serves as a versatile reagent in multiple catalytic and coupling reactions. It is utilized in copper-mediated ligandless aerobic fluoroalkylation and palladium-catalyzed aerobic oxidative cross-coupling reactions. Its applications extend to the use of recyclable magnetic-nanoparticle-supported palladium catalysts in Suzuki coupling reactions, as well as oxidative hydroxylation via copper catalysts. The compound facilitates ligand-free palladium-catalyzed Suzuki-Miyaura cross-coupling, homocoupling with gold salts, and ruthenium-catalyzed cross-coupling. It also plays a role in CuI-catalyzed Suzuki coupling reactions and the complex palladium-catalyzed domino Heck-Mizoroki/Suzuki-Miyaura reactions. Additionally, it is involved in manganese triacetate-mediated radical additions of arylboronic acids to alkenes and is employed in the preparation of Pleuromutilin derivatives for ribosomal binding and antibacterial activity through "Click Chemistry," as well as in the creation of liquid crystalline polyacetylene derivatives.
Molecular Weight
247.83
Molecular Formula
C6H6BIO2
Product Information
Canonical SMILES
B(C1=CC=C(C=C1)I)(O)O
InChI
InChI=1S/C6H6BIO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
InChI Key
PELJYVULHLKXFF-UHFFFAOYSA-N
Melting Point
286 °C
Appearance
White to Almost white powder to crystal
Complexity
102
Exact Mass
247.95056g/mol
Hazard Statements
H315 : Causes skin irritation.H319 : Causes serious eye irritation.
Heavy Atom Count
10
MDL Number
MFCD01319014
Monoisotopic Mass
247.95056g/mol
Precautionary Statements
P264 : Wash skin thoroughly after handling.P280 : Wear protective gloves/ eye protection/ face protection.P337 + P313 : If eye irritation persists: Get medical advice/ attention.P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.P332 + P313 : If skin irritation occurs: Get medical advice/ attention.P362 : Take off contaminated clothing and wash before reuse.
Reaxys Registry Number
2936348
Rotatable Bond Count
1
Signal Word
Warning
Please kindly note that our products and services are for research use only.
Have a question? Get a Free Consultation