Allyltrimethoxysilane
Catalog Number
ACM2551839
CAS
2551-83-9
IUPAC Name
Trimethoxy(prop-2-enyl)silane
Synonyms
3-(Trimethoxysilyl)-1-propene
Application
Allyltrimethoxysilane is a versatile chemical reagent primarily used for the introduction of allyl groups into various organic compounds. This clear to slightly cloudy liquid is instrumental in the allylation of carbonyl compounds, such as aldehydes, ketones, and imines, facilitating the formation of homoallylic alcohols and amines through the creation of new carbon-carbon bonds. Additionally, it is utilized in the synthesis of homoallylic α-branched amines from both aromatic and aliphatic aldehyde and ketone hydrazones. Its ability to induce double bond formation is particularly valuable in modifying porous silica, aiding in the preparation of chiral stationary phases. Furthermore, Allyltrimethoxysilane excels in the regioselective generation of enol trimethoxysilyl ethers, which are crucial for asymmetric synthesis involving quaternary carbon centers. It also plays a role in transforming arylselenyl bromides to arylallylselenides, allylating aryl iodides, and participating in silver-catalyzed asymmetric allylation, showcasing its broad application in organic synthesis.
Molecular Weight
162.26
Molecular Formula
C6H14O3Si
Product Information
Canonical SMILES
CO[Si](CC=C)(OC)OC
InChI
InChI=1S/C6H14O3Si/c1-5-6-10(7-2,8-3)9-4/h5H,1,6H2,2-4H3
InChI Key
LFRDHGNFBLIJIY-UHFFFAOYSA-N
Boiling Point
146-148 °C
Flash Point
88 °F
Purity
95%+
Density
0.963 g/mL at 25 °C (lit.)
Appearance
Light yellow liquid
Storage
Inert atmosphere,2-8 °C
Complexity
92.9
Covalently-Bonded Unit Count
1
Exact Mass
162.07122084
Hazard Statements
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H226 : Flammable liquid and vapour.
H319 : Causes serious eye irritation.
H226 : Flammable liquid and vapour.
Heavy Atom Count
10
MDL Number
MFCD00053865
Monoisotopic Mass
162.07122084
Precautionary Statements
P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
Reaxys Registry Number
2350745
Refractive Index
n20/D 1.405 (lit.)
Rotatable Bond Count
5
Signal Word
Warning
Specific Gravity
0.97
Topological Polar Surface Area
27.7 Ų
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