4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical
Catalog Number
ACM2226962-1
CAS
2226-96-2
Synonyms
4-Hydroxy-TEMPO Free Radical
Application
The purpose of 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical, commonly known as 4-hydroxy-TEMPO, is multifaceted, serving as a critical component in both scientific research and industrial applications. In the realm of biochemical research, it functions as a potent agent to mitigate reactive oxygen species, owing to its superoxide dismutase (SOD) mimetic activity, which allows it to inhibit lipid peroxidation effectively and quench superoxide anions. It is particularly valuable for its ability to catalyze superoxide disproportionation and facilitate hydrogen peroxide metabolism, making it instrumental in limiting oxidative stress within biological systems. In vitro studies have demonstrated its efficacy in significantly reducing superoxide anion production, while in vivo it can lower blood pressure and heart rate in hypertensive models. Additionally, 4-hydroxy-TEMPO's role as an efficient spin label facilitates the quantification of intracellular oxygen using electron spin resonance spectroscopy. On an industrial scale, it is utilized for its antioxidant properties and as a structural component in hindered amine light stabilizers, which enhance the durability of plastics. It also serves as a polymerization inhibitor, particularly valuable during styrene purification, making it indispensable in various chemical processes.
Molecular Weight
172.25
Molecular Formula
C9H18NO2
Product Information
InChI
InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChI Key
UZFMOKQJFYMBGY-UHFFFAOYSA-N
Melting Point
72 °C
Purity
>98.0%(GC)
Solubility
soluble in Methanol
Appearance
Light yellow to Amber to Dark green powder to crystal
Storage
Store under inert gas
Condition to avoid
Light Sensitive,Hygroscopic
Hazard Statements
H302 : Harmful if swallowed.H315 : Causes skin irritation.H319 : Causes serious eye irritation.
MDL Number
MFCD00006478
Precautionary Statements
P501 : Dispose of contents/ container to an approved waste disposal plant.P270 : Do not eat, drink or smoke when using this product.P264 : Wash skin thoroughly after handling.P280 : Wear protective gloves/ eye protection/ face protection.P337 + P313 : If eye irritation persists: Get medical advice/ attention.P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.P332 + P313 : If skin irritation occurs: Get medical advice/ attention.P362 : Take off contaminated clothing and wash before reuse.P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Reaxys Registry Number
11328213
Signal Word
Warning
Solubility In Water
Soluble
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